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Cross-reactive antibodies induced by previous infections with endemic human coronaviruses (hCoVs) were much debated early in the pandemic as potential mediators of cross-protection or induction of antibody-dependent enhancement (ADE) of infection, though in vivo evidence for ADE in coronavirus infections is very limited [91]

This finding was replicated in cultured astrocytes, whereas homogeneous neuronal cultures are too short-lived to provide meaningful results

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Furthermore, other investigators measured only free elements in serum, except the elements bound to proteins

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